Mouse Trib3 Antibody
Product Specifications
Background
Trib3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
NCBI Gene ID
228775
Swiss Prot
Q8K4K2
Accession Number
Q8K4K2
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Trib3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-334 amino acids from the C-terminal region of mouse Trib3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Trib3
NCBI Official Name
Tribbles homolog 3
NCBI Organism
Mus musculus
Background Reference 01
Morse, E., et al. Am. J. Physiol. Renal Physiol. 299 (5), F965-F972 (2010) :
Background Reference 02
Dedhia, P.H., et al. Blood 116 (8) :1321-1328 (2010)
Background Reference 03
Liew, C.W., et al. J. Clin. Invest. 120 (8) :2876-2888 (2010)
Background Reference 04
Humphrey, R.K., et al. J. Biol. Chem. 285 (29) :22426-22436 (2010)
Other Product Names
Tribbles homolog 3, TRB-3, Neuronal cell death-inducible putative kinase, Trib3, Nipk, Trb3
Tested Applications
WB
Physical Properties
Liquid
Frequently Asked Questions
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