Mouse Trib3 Antibody

Product Specifications

Background

Trib3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.

NCBI Gene ID

228775

Swiss Prot

Q8K4K2

Accession Number

Q8K4K2

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Trib3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-334 amino acids from the C-terminal region of mouse Trib3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Trib3

NCBI Official Name

Tribbles homolog 3

NCBI Organism

Mus musculus

Background Reference 01

Morse, E., et al. Am. J. Physiol. Renal Physiol. 299 (5), F965-F972 (2010) :

Background Reference 02

Dedhia, P.H., et al. Blood 116 (8) :1321-1328 (2010)

Background Reference 03

Liew, C.W., et al. J. Clin. Invest. 120 (8) :2876-2888 (2010)

Background Reference 04

Humphrey, R.K., et al. J. Biol. Chem. 285 (29) :22426-22436 (2010)

Other Product Names

Tribbles homolog 3, TRB-3, Neuronal cell death-inducible putative kinase, Trib3, Nipk, Trb3

Tested Applications

Physical Properties

Liquid

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