CNOT2 Antibody

Product Specifications

Background

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.

NCBI Gene ID

4848

Swiss Prot

Q9NZN8

Accession Number

Q9NZN8

Host

Rabbit

Reactivity

Human

Immunogen

This CNOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the Central region of human CNOT2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CNOT2

NCBI Official Name

CCR4-NOT transcription complex subunit 2

NCBI Organism

Homo sapiens

Background Reference 01

Lau, N.C., et al. Biochem. J. 422 (3) :443-453 (2009)

Background Reference 02

Miyasaka, T., et al. Cancer Sci. 99 (4) :755-761 (2008)

Background Reference 03

Morita, M., et al. Mol. Cell. Biol. 27 (13) :4980-4990 (2007)

Background Reference 04

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Other Product Names

CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2

Tested Applications

Protein ID

46396017

Physical Properties

Liquid

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