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L3MBTL2 Antibody

Product Specifications

Background

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

NCBI Gene ID

83746

Swiss Prot

Q969R5

Accession Number

Q969R5

Host

Rabbit

Reactivity

Human

Immunogen

This L3MBTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 627-656 amino acids from the C-terminal region of human L3MBTL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

79 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

L3MBTL2

NCBI Official Name

Lethal (3) malignant brain tumor-like protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Guo, Y., et al. Nucleic Acids Res. 37 (7) :2204-2210 (2009)

Background Reference 02

Lechtenberg, B.C., et al. Protein Sci. 18 (3) :657-661 (2009)

Background Reference 03

Trojer, P., et al. Cell 129 (5) :915-928 (2007)

Background Reference 04

Collins, J.E., et al. Genome Biol. (10), R84 (2004) :

Other Product Names

Lethal (3) malignant brain tumor-like protein 2, H-l (3) mbt-like protein 2, L (3) mbt-like protein 2, L3MBTL2

Tested Applications

WB

Protein ID

27734418

Physical Properties

Liquid

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