EGLN3 Antibody
Product Specifications
Background
EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism (By similarity) .
NCBI Gene ID
112399
Swiss Prot
Q9H6Z9
Accession Number
Q9H6Z9
Host
Rabbit
Reactivity
Human
Immunogen
This EGLN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human EGLN3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-569
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Symbol
EGLN3
NCBI Official Name
Egl nine homolog 3
NCBI Organism
Homo sapiens
Background Reference 01
Sato, M., et al. Exp. Cell Res. 316 (17) :2871-2882 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Xue, J., et al. Gastroenterology 138 (2) :606-615 (2010)
Background Reference 04
Henze, A.T., et al. Cancer Res. 70 (1) :357-366 (2010)
Other Product Names
Egl nine homolog 3, HPH-1, Hypoxia-inducible factor prolyl hydroxylase 3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-3, Prolyl hydroxylase domain-containing protein 3, PHD3, EGLN3
Tested Applications
WB, IHC-P
Protein ID
32129515
Physical Properties
Liquid
Curated Selection
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