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MCPH1 Antibody

Product Specifications

Background

This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.

NCBI Gene ID

79648

Swiss Prot

Q8NEM0

Accession Number

Q8NEM0

Host

Rabbit

Reactivity

Human

Immunogen

This MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human MCPH1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-564

Calculated Molecular Weight

93 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MCPH1

NCBI Official Name

Microcephalin

NCBI Organism

Homo sapiens

Background Reference 01

Wang, Y., et al. J. Hum. Genet. 55 (8) :490-494 (2010)

Background Reference 02

Ruano, G., et al. Pharmacogenomics 11 (7) :959-971 (2010)

Background Reference 03

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 04

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Other Product Names

Microcephalin, MCPH1

Tested Applications

WB

Protein ID

296439305

Physical Properties

Liquid

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