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NR2E3 Antibody

Product Specifications

Background

This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI Gene ID

10002

Swiss Prot

Q9Y5X4

Accession Number

Q9Y5X4

Host

Rabbit

Reactivity

Human

Immunogen

This NR2E3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the Central region of human NR2E3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NR2E3

NCBI Official Name

Photoreceptor-specific nuclear receptor

NCBI Organism

Homo sapiens

Background Reference 01

Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)

Background Reference 02

Yang, Y., et al. Invest. Ophthalmol. Vis. Sci. 51 (4) :2229-2235 (2010)

Background Reference 03

Khan, A.O., et al. Arch. Ophthalmol. 128 (3) :344-348 (2010)

Background Reference 04

Kanda, A., et al. Mol. Vis. 15, 2174-2184 (2009) :

Other Product Names

Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor, NR2E3, PNR, RNR

Tested Applications

WB

Protein ID

8928275

Physical Properties

Liquid

Frequently Asked Questions

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