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COL2A1 Antibody

Product Specifications

Background

Alpha-1 chain of type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutant forms of this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.

NCBI Gene ID

1280

Swiss Prot

P02458

Accession Number

P02458

Host

Rabbit

Reactivity

Human

Immunogen

This COL2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1209-1237 amino acids from the C-terminal region of human COL2A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-548

Calculated Molecular Weight

142 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

COL2A1

NCBI Official Name

Collagen alpha-1 (II) chain

NCBI Organism

Homo sapiens

Background Reference 01

Olavarrieta, L., Clin. Genet. 73 (3), 262-267 (2008)

Background Reference 02

McAlinden, A., Hum. Mutat. 29 (1), 83-90 (2008)

Background Reference 03

Forzano, F., Am. J. Med. Genet.143 (23), 2815-2820 (2007)

Other Product Names

Collagen alpha-1 (II) chain, Alpha-1 type II collagen, Collagen alpha-1 (II) chain, Chondrocalcin, COL2A1

Tested Applications

WB

Protein ID

124056489

Physical Properties

Liquid

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