GNAQ Antibody

Product Specifications

Background

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.

NCBI Gene ID

2776

Swiss Prot

P50148

Accession Number

P50148

Host

Rabbit

Reactivity

Human

Immunogen

This GNAQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human GNAQ.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GNAQ

NCBI Official Name

Guanine nucleotide-binding protein G (q) subunit alpha

NCBI Organism

Homo sapiens

Background Reference 01

Dratviman-Storobinsky, O., et al. Invest. Ophthalmol. Vis. Sci. 51 (12) :6180-6182 (2010)

Background Reference 02

Crouthamel, M., et al. Mol. Pharmacol. 78 (4) :767-777 (2010)

Background Reference 03

Chillar, A., et al. Biochemistry 49 (30) :6365-6374 (2010)

Background Reference 04

Klenke, S., et al. Pharmacogenet. Genomics 20 (8) :476-484 (2010)

Other Product Names

Guanine nucleotide-binding protein G (q) subunit alpha, Guanine nucleotide-binding protein alpha-q, GNAQ, GAQ

Tested Applications

Protein ID

251757492

Physical Properties

Liquid

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