NUP88 Antibody

Product Specifications

Background

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.

NCBI Gene ID

4927

Swiss Prot

Q99567

Accession Number

Q99567

Host

Rabbit

Reactivity

Human

Immunogen

This NUP88 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-730 amino acids from the C-terminal region of human NUP88.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

84 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NUP88

NCBI Official Name

Nuclear pore complex protein Nup88

NCBI Organism

Homo sapiens

Background Reference 01

Hashizume, C., et al. Mol. Cancer 9, 119 (2010) :

Background Reference 02

Brustmann, H., et al. Ann Diagn Pathol 13 (5) :303-307 (2009)

Background Reference 03

Cheng, Y.T., et al. Plant Cell 21 (8) :2503-2516 (2009)

Background Reference 04

Andres-Hernando, A., et al. J. Biol. Chem. 283 (36) :25082-25090 (2008)

Other Product Names

Nuclear pore complex protein Nup88, 88 kDa nucleoporin, Nucleoporin Nup88, NUP88

Tested Applications

Protein ID

25008854

Physical Properties

Liquid

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