TRAP1 Antibody

Product Specifications

Background

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. TRAP1 is a mitochondrial HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and endoplasmic reticulum (HSP90B1; MIM 191175) (Chen et al., 2005 [PubMed 16269234]) .

NCBI Gene ID

10131

Swiss Prot

Q12931

Accession Number

Q12931

Host

Rabbit

Reactivity

Human

Immunogen

This TRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 542-570 amino acids from the C-terminal region of human TRAP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

80 kDa

Fragment

Rabbit Ig

Symbol

TRAP1

NCBI Official Name

Heat shock protein 75 kDa, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Liu, D., et al. Cancer Lett. 296 (2) :194-205 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Nguyen, M.C., et al. Cancer Immunol. Immunother. 59 (9) :1313-1323 (2010)

Background Reference 04

Landriscina, M., et al. Cancer Res. 70 (16) :6577-6586 (2010)

Other Product Names

Heat shock protein 75 kDa, mitochondrial, HSP 75, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1, TRAP1, HSP75