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APLNR Antibody

Product Specifications

Background

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.

NCBI Gene ID

187

Swiss Prot

P35414

Accession Number

P35414

Host

Rabbit

Reactivity

Human

Immunogen

This APLNR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the Central region of human APLNR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-494

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

APLNR

NCBI Official Name

Apelin receptor

NCBI Organism

Homo sapiens

Background Reference 01

Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51 (8) :4237-4242 (2010)

Background Reference 02

Zhao, Q., et al. Am. J. Hypertens. 23 (6) :606-613 (2010)

Background Reference 03

Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395 (2) :185-189 (2010)

Background Reference 04

Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14 (3) :231-241 (2010)

Other Product Names

Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ

Tested Applications

WB

Protein ID

543823

Physical Properties

Liquid

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