CFL2 Antibody
Product Specifications
Background
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
1073
Swiss Prot
Q9Y281
Accession Number
Q9Y281
Host
Rabbit
Reactivity
Human
Immunogen
This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human CFL2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-488
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Symbol
CFL2
NCBI Official Name
Cofilin-2
NCBI Organism
Homo sapiens
Background Reference 01
Vogel, S., et al. J. Biol. Chem. 285 (44) :33756-33763 (2010) Borensztajn, K., et al. Thromb. Res. 125 (6), E323-E328 (2010) Papalouka, V., et al. Mol. Cell. Biol. 29 (22) :6046-6058 (2009) Wu, Y., et al. Retrovirology 5, 95 (2008) Agrawal, P.B., et al. Am. J. Hum. Genet. 80 (1) :162-167 (2007)
Other Product Names
Cofilin-2, Cofilin, muscle isoform, CFL2
Tested Applications
WB, IHC-P
Protein ID
6831517
Physical Properties
Liquid
Curated Selection
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