CFL2 Antibody

Product Specifications

Background

This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

1073

Swiss Prot

Q9Y281

Accession Number

Q9Y281

Host

Rabbit

Reactivity

Human

Immunogen

This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human CFL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

19 kDa

Fragment

Rabbit Ig

Symbol

CFL2

NCBI Official Name

Cofilin-2

NCBI Organism

Homo sapiens

Background Reference 01

Vogel, S., et al. J. Biol. Chem. 285 (44) :33756-33763 (2010) Borensztajn, K., et al. Thromb. Res. 125 (6), E323-E328 (2010) Papalouka, V., et al. Mol. Cell. Biol. 29 (22) :6046-6058 (2009) Wu, Y., et al. Retrovirology 5, 95 (2008) Agrawal, P.B., et al. Am. J. Hum. Genet. 80 (1) :162-167 (2007)