PNKP Antibody
Product Specifications
Background
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
NCBI Gene ID
11284
Swiss Prot
Q96T60
Accession Number
Q96T60
Host
Rabbit
Reactivity
Human
Immunogen
This PNKP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the N-terminal region of human PNKP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-487
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PNKP
NCBI Official Name
Bifunctional polynucleotide phosphatase/kinase
NCBI Organism
Homo sapiens
Background Reference 01
Arora, M., et al. Leukemia 24 (8) :1470-1475 (2010)
Background Reference 02
Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16 (8) :1084-1089 (2010)
Background Reference 03
Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)
Background Reference 04
Shen, J., et al. Nat. Genet. 42 (3) :245-249 (2010)
Other Product Names
Bifunctional polynucleotide phosphatase/kinase, DNA 5'-kinase/3'-phosphatase, Polynucleotide kinase-3'-phosphatase, Polynucleotide 3'-phosphatase, 2' (3') -polynucleotidase, Polynucleotide 5'-hydroxyl-kinase, PNKP
Tested Applications
WB
Protein ID
50401132
Physical Properties
Liquid
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