TARBP2 Antibody

Product Specifications

Background

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.

NCBI Gene ID

6895

Swiss Prot

Q15633

Accession Number

Q15633

Host

Rabbit

Reactivity

Human

Immunogen

This TARBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human TARBP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Symbol

TARBP2

NCBI Official Name

RISC-loading complex subunit TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}

NCBI Organism

Homo sapiens

Background Reference 01

Garre, P., et al. Nat. Genet. 42 (10) :817-818 (2010)

Background Reference 02

Wilker, E.H., et al. Environ. Health Perspect. 118 (7) :943-948 (2010)

Background Reference 03

Boni, V., et al. Pharmacogenomics J. (2010) In press :

Background Reference 04

Wang, H.W., et al. Nat. Struct. Mol. Biol. 16 (11) :1148-1153 (2009)

Other Product Names

RISC-loading complex subunit TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TRBP