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RHOC Antibody

Product Specifications

Background

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

NCBI Gene ID

389

Swiss Prot

P08134

Accession Number

P08134

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-478

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

RHOC

NCBI Official Name

Rho-related GTP-binding protein RhoC

NCBI Organism

Homo sapiens

Background Reference 01

Jiang, L., et al. Int. J. Cancer 127 (3) :505-512 (2010)

Background Reference 02

Wu, M., et al. Cancer 116 (11 SUPPL), 2768-2782 (2010) :

Background Reference 03

Lipkin, S.M., et al. Cancer Prev Res (Phila) 3 (5) :597-603 (2010)

Background Reference 04

Kitzing, T.M., et al. Oncogene 29 (16) :2441-2448 (2010)

Other Product Names

Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC

Tested Applications

WB

Protein ID

132543

Physical Properties

Liquid

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