NMNAT3 Antibody

Product Specifications

Background

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca (2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 [PubMed 12574164]) .

NCBI Gene ID

349565

Swiss Prot

Q96T66

Accession Number

Q96T66

Host

Rabbit

Reactivity

Human

Immunogen

This NMNAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from the Central region of human NMNAT3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NMNAT3

NCBI Official Name

Nicotinamide mononucleotide adenylyltransferase 3

NCBI Organism

Homo sapiens

Background Reference 01

Di Stefano, M., et al. Blood Cells Mol. Dis. 45 (1) :33-39 (2010)

Background Reference 02

Lau, C., et al. J. Biol. Chem. 285 (24) :18868-18876 (2010)

Background Reference 03

Sorci, L., et al. Biochemistry 46 (16) :4912-4922 (2007)

Background Reference 04

Berger, F., et al. J. Biol. Chem. 280 (43) :36334-36341 (2005)

Other Product Names

Nicotinamide mononucleotide adenylyltransferase 3, NMN adenylyltransferase 3, Nicotinate-nucleotide adenylyltransferase 3, NaMN adenylyltransferase 3, Pyridine nucleotide adenylyltransferase 3, PNAT-3, NMNAT3