ADAM11 Antibody

Product Specifications

Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq].

NCBI Gene ID

4185

Swiss Prot

O75078

Accession Number

O75078

Host

Rabbit

Reactivity

Human

Immunogen

This ADAM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the N-terminal region of human ADAM11.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

83 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:500

Symbol

ADAM11

NCBI Official Name

Disintegrin and metalloproteinase domain-containing protein 11

NCBI Organism

Homo sapiens

Background Reference 01

Fu, G.K., et al. Genomics 84 (1) :205-210 (2004)

Background Reference 02

Hillman, R.T., et al. Genome Biol. (2), R8 (2004) :

Background Reference 03

Shea, S.H., et al. Behav. Genet. 31 (2) :231-239 (2001)

Background Reference 04

Sagane, K., et al. Biochem. J. 334 (PT 1), 93-98 (1998) :

Other Product Names

Disintegrin and metalloproteinase domain-containing protein 11, ADAM 11, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein, MDC, ADAM11, MDC