UBP1 Antibody

Product Specifications

Background

UBP1 functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity) . Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.

NCBI Gene ID

7342

Swiss Prot

Q9NZI7

Accession Number

Q9NZI7

Host

Rabbit

Reactivity

Human

Immunogen

This UBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of human UBP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

UBP1

NCBI Official Name

Upstream-binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Katsura, A., et al. Genes Cells 14 (10) :1183-1196 (2009)

Background Reference 02

Koutnikova, H., et al. PLoS Genet. (8), E1000591 (2009) :

Background Reference 03

Henderson, Y.C., et al. DNA Cell Biol. 27 (2) :71-79 (2008)

Background Reference 04

Huang, N., et al. Mol. Endocrinol. 19 (2) :409-420 (2005)

Other Product Names

Upstream-binding protein 1, Transcription factor LBP-1, UBP1, LBP1

Tested Applications

WB, IHC-P, IF

Protein ID

74719655

Physical Properties

Liquid

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