BAG2 Antibody

Product Specifications

Background

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq].

NCBI Gene ID

9532

Swiss Prot

O95816

Accession Number

O95816

Host

Rabbit

Reactivity

Human

Immunogen

This BAG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the C-terminal region of human BAG2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

24 kDa

Fragment

Rabbit Ig

Symbol

BAG2

NCBI Official Name

BAG family molecular chaperone regulator 2

NCBI Organism

Homo sapiens

Background Reference 01

Arndt, V., et al. Mol. Biol. Cell 16 (12) :5891-5900 (2005)

Background Reference 02

Dai, Q., et al. J. Biol. Chem. 280 (46) :38673-38681 (2005)

Background Reference 03

Ueda, K., et al. J. Biol. Chem. 279 (40) :41815-41821 (2004)

Background Reference 04

Ueda, K., et al. J. Biol. Chem. 279 (40) :41815-41821 (2004)

Other Product Names

BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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