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GRIA3 Antibody

Product Specifications

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) -sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G) . Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.

NCBI Gene ID

2892

Swiss Prot

P42263

Accession Number

P42263

Host

Rabbit

Reactivity

Human

Immunogen

This GRIA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the N-terminal region of human GRIA3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-436

Calculated Molecular Weight

101 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GRIA3

NCBI Official Name

Glutamate receptor 3

NCBI Organism

Homo sapiens

Background Reference 01

Ripka, S., et al. Neoplasia 12 (8) :659-667 (2010)

Background Reference 02

Liu, Q., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26 (4) :376-378 (2010)

Background Reference 03

Feyissa, A.M., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34 (2) :279-283 (2010)

Background Reference 04

Marek, G.J., et al. Mol. Pharmacol. 77 (3) :317-326 (2010)

Other Product Names

Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3, GRIA3, GLUR3, GLURC

Tested Applications

WB

Protein ID

77416864

Physical Properties

Liquid

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