MCM3 Antibody

Product Specifications

Background

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq].

NCBI Gene ID

4172

Swiss Prot

P25205

Accession Number

P25205

Host

Rabbit

Reactivity

Human

Immunogen

This MCM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human MCM3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

91 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MCM3

NCBI Official Name

DNA replication licensing factor MCM3

NCBI Organism

Homo sapiens

Background Reference 01

Lau, K.M., et al. Oncogene 29 (40) :5475-5489 (2010)

Background Reference 02

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 03

Lee, Y.S., et al. Exp. Mol. Pathol. 88 (1) :138-142 (2010)

Background Reference 04

Song, Y.J., et al. Acta Virol. 54 (2) :125-130 (2010)

Other Product Names

DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3

Tested Applications

Protein ID

19857543

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-90126AF532 0.1 mL

Rabbit Monoclonal FABP6 Antibody (009) [Alexa Fluor 532]

Ask

View Details

QM69766S 200 Tests

Mouse H4c18 qPCR Primer Pair

Ask

View Details

TA389556 100 µg

Anti-CLEC1A antibody(DMC468), IgG1 Chimeric mAb

Ask

View Details

H00004212-M03 0.1 mg

Mouse Monoclonal MEIS2 Antibody (1D1)

Ask

View Details

MBS1062080-01 0.02 mg (E-Coli)

Recombinant Actinobacillus pleuropneumoniae serotype 7 L-fucose mutarotase (fucU)

Ask

View Details

MBS1062080-02 0.1 mg (E-Coli)

Recombinant Actinobacillus pleuropneumoniae serotype 7 L-fucose mutarotase (fucU)

Ask

View Details