SUV39H1 Antibody

Product Specifications

Background

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

NCBI Gene ID

6839

Swiss Prot

O43463

Accession Number

O43463

Host

Rabbit

Reactivity

Human

Immunogen

This SUV39H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the N-terminal region of human SUV39H1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SUV39H1

NCBI Official Name

Histone-lysine N-methyltransferase SUV39H1

NCBI Organism

Homo sapiens

Background Reference 01

Chen, L., et al. EMBO J. 29 (15) :2538-2552 (2010)

Background Reference 02

Goyama, S., et al. Leukemia 24 (1) :81-88 (2010)

Background Reference 03

Cherrier, T., et al. Oncogene 28 (38) :3380-3389 (2009)

Background Reference 04

Li, Z., et al. J. Biol. Chem. 284 (16) :10361-10366 (2009)

Other Product Names

Histone-lysine N-methyltransferase SUV39H1, Histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, Lysine N-methyltransferase 1A, Position-effect variegation 3-9 homolog, Suppressor of variegation 3-9 homolog 1, Su (var) 3-9 homolog 1, SUV39H1, KMT1A, SUV39H