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CDH4 Antibody

Product Specifications

Background

CDH4 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.

NCBI Gene ID

1002

Swiss Prot

P55283

Accession Number

P55283

Host

Rabbit

Reactivity

Human

Immunogen

This CDH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-203 amino acids from the N-terminal region of human CDH4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-420

Calculated Molecular Weight

100 kDa

Fragment

Rabbit Ig

Symbol

CDH4

NCBI Official Name

Cadherin-4

NCBI Organism

Homo sapiens

Background Reference 01

Miotto, E., Cancer Res. 64 (22), 8156-8159 (2004)

Background Reference 02

Johnson, E., J. Biol. Chem. 279 (30), 31041-31049 (2004)

Background Reference 03

Kitagawa, M., Biochem. Biophys. Res. Commun. 271 (2), 358-363 (2000)

Other Product Names

Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

81175161

Physical Properties

Liquid

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