CHRNA5 Antibody

Product Specifications

Background

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2) .

NCBI Gene ID

1138

Swiss Prot

P30532

Accession Number

P30532

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CHRNA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human CHRNA5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CHRNA5

NCBI Official Name

Neuronal acetylcholine receptor subunit alpha-5

NCBI Organism

Homo sapiens

Background Reference 01

Wessel, J., et al. Neuropsychopharmacology 35 (12) :2392-2402 (2010)

Background Reference 02

Erlich, P.M., et al. Hum. Genet. 128 (5) :491-499 (2010)

Background Reference 03

Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

Background Reference 04

Falvella, F.S., et al. J. Natl. Cancer Inst. 102 (17) :1366-1370 (2010)

Other Product Names

Neuronal acetylcholine receptor subunit alpha-5, CHRNA5, NACHRA5

Tested Applications

Protein ID

2506126

Physical Properties

Liquid

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