FCGR2B Antibody

Product Specifications

Background

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE) . Several transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

2213

Swiss Prot

P31994

Accession Number

P31994

Host

Rabbit

Reactivity

Human

Immunogen

This FCGR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human FCGR2B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

34 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FCGR2B

NCBI Official Name

Low affinity immunoglobulin gamma Fc region receptor II-b

NCBI Organism

Homo sapiens

Background Reference 01

Prokopec, K.E., et al. Clin. Immunol. 137 (3) :322-329 (2010)

Background Reference 02

Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)

Background Reference 03

Zhang, C.Y., et al. J. Biol. Chem. 285 (44) :34250-34258 (2010)

Background Reference 04

Niederer, H.A., et al. Hum. Mol. Genet. 19 (16) :3282-3294 (2010)

Other Product Names

Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2