What is the catalog number for ACK1 Antibody?

The catalog number for ACK1 Antibody is 57-363.

What sizes are available for ACK1 Antibody?

ACK1 Antibody is available in the following size(s): 400 µL.

Is ACK1 Antibody in stock?

ACK1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

ACK1 Antibody

Product Specifications

Background

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

NCBI Gene ID

10188

Swiss Prot

Q07912

Accession Number

Q07912

Host

Rabbit

Reactivity

Human

Immunogen

This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-290 amino acids from the Central region of human ACK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

115 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TNK2

NCBI Official Name

Activated CDC42 kinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Mahajan, K., et al. J. Cell. Physiol. 224 (2) :327-333 (2010)

Background Reference 02

Chua, B.T., et al. Mol Oncol 4 (4) :323-334 (2010)

Background Reference 03

Prieto-Echague, V., et al. J. Biol. Chem. 285 (14) :10605-10615 (2010)

Background Reference 04

Lin, Q., et al. Mol. Cell. Biol. 30 (6) :1541-1554 (2010)

Other Product Names

Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1

Tested Applications

Protein ID

229462980

Physical Properties

Liquid

Frequently Asked Questions

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