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Mouse Nlk Antibody

Product Specifications

Background

Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.

NCBI Gene ID

18099

Swiss Prot

O54949

Accession Number

O54949

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Mouse Nlk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of mouse Nlk.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Symbol

Nlk

NCBI Official Name

Serine/threonine-protein kinase NLK

NCBI Organism

Mus musculus

Background Reference 01

Li, M., et al. J. Biol. Chem. 285 (18) :13397-13404 (2010)

Background Reference 02

Nifuji, A., et al. Exp. Cell Res. 316 (7) :1127-1136 (2010)

Background Reference 03

Ishitani, T., et al. Nat. Cell Biol. 12 (3) :278-285 (2010)

Background Reference 04

Martinez, G., et al. Invest. Ophthalmol. Vis. Sci. 50 (10) :4794-4806 (2009)

Other Product Names

Serine/threonine-protein kinase NLK, Nemo-like kinase, Nlk {ECO:0000312|EMBL:AAC244991}

Tested Applications

WB, IHC-P

Physical Properties

Liquid

Frequently Asked Questions

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