Mouse Abl1 Antibody

Product Specifications

Background

Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

NCBI Gene ID

11350

Swiss Prot

P00520

Accession Number

P00520

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the Central region of mouse Abl1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

123 kDa

Fragment

Rabbit Ig

Symbol

Abl1

NCBI Official Name

Tyrosine-protein kinase ABL1

NCBI Organism

Mus musculus

Background Reference 01

Ko, H.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (38) :16691-16696 (2010)

Background Reference 02

Yamaguchi, T., et al. Apoptosis 15 (8) :927-935 (2010)

Background Reference 03

Michael, M., et al. Curr. Biol. 20 (9) :783-791 (2010)

Background Reference 04

Swimm, A.I., et al. J. Virol. 84 (9) :4243-4251 (2010)

Other Product Names

Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Abl1, Abl