PPP1CB Antibody

Product Specifications

Background

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1) . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.

NCBI Gene ID

5500

Swiss Prot

P62140

Accession Number

P62140

Host

Rabbit

Reactivity

Human

Immunogen

This PPP1CB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the C-terminal region of human PPP1CB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse, Pig, Rabbit, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PPP1CB

NCBI Official Name

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

NCBI Organism

Homo sapiens

Background Reference 01

Lee, J.H., et al. J. Biol. Chem. 285 (32) :24466-24476 (2010)

Background Reference 02

Fujiki, R., et al. Nature 459 (7245) :455-459 (2009)

Background Reference 03

Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18 (1) :255-259 (2009)

Background Reference 04

Sueyoshi, T., et al. Mol. Pharmacol. 73 (4) :1113-1121 (2008)

Other Product Names

Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP-1B, PPP1CD, PPP1CB

Tested Applications

Protein ID

49065814

Physical Properties

Liquid

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