VAV1 Antibody
Product Specifications
Background
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
NCBI Gene ID
7409
Swiss Prot
P15498
Accession Number
P15498
Host
Rabbit
Reactivity
Human
Immunogen
This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human VAV1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
98 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
VAV1
NCBI Official Name
Proto-oncogene vav
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Hollmann, A., et al. Hematol Oncol 28 (3) :142-150 (2010)
Background Reference 03
Barda-Saad, M., et al. EMBO J. 29 (14) :2315-2328 (2010)
Background Reference 04
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Other Product Names
Proto-oncogene vav, VAV1, VAV
Tested Applications
WB
Protein ID
13124807
Physical Properties
Liquid
Curated Selection
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