CENPA Antibody

Product Specifications

Background

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].

NCBI Gene ID

1058

Swiss Prot

P49450

Accession Number

P49450

Host

Rabbit

Reactivity

Human

Immunogen

This CENPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the Central region of human CENPA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Hamster

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

16 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CENPA

NCBI Official Name

Histone H3-like centromeric protein A

NCBI Organism

Homo sapiens

Background Reference 01

Sekulic, N., et al. Nature 467 (7313) :347-351 (2010)

Background Reference 02

Carroll, C.W., et al. J. Cell Biol. 189 (7) :1143-1155 (2010)

Background Reference 03

Maehara, K., et al. Mol. Cell. Biol. 30 (9) :2090-2104 (2010)

Background Reference 04

Buscaino, A., et al. Curr. Opin. Genet. Dev. 20 (2) :118-126 (2010)

Other Product Names

Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A, CENPA

Tested Applications

Protein ID

1345726

Physical Properties

Liquid

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