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XPA Antibody

Product Specifications

Background

This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

NCBI Gene ID

7507

Swiss Prot

P23025

Accession Number

P23025

Host

Rabbit

Reactivity

Human

Immunogen

This XPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the C-terminal region of human XPA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

31 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

XPA

NCBI Official Name

DNA repair protein complementing XP-A cells

NCBI Organism

Homo sapiens

Background Reference 01

Palli, D., et al. Mutagenesis 25 (6) :569-575 (2010)

Background Reference 02

Fan, W., et al. Mol. Cell 39 (2) :247-258 (2010)

Background Reference 03

Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :

Background Reference 04

Hsieh, Y.Y., et al. Anticancer Res. 30 (6) :2203-2208 (2010)

Other Product Names

DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein, XPA, XPAC

Tested Applications

WB

Protein ID

139816

Physical Properties

Liquid

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