POF1B Antibody
Product Specifications
Background
Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.
NCBI Gene ID
79983
Swiss Prot
Q8WVV4
Accession Number
Q8WVV4
Host
Rabbit
Reactivity
Mouse
Immunogen
This POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the Central region of human POF1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
POF1B
NCBI Official Name
Protein POF1B
NCBI Organism
Homo sapiens
Background Reference 01
Rizzolio, F., et al. Gene Expr. Patterns 7 (4) :529-534 (2007)
Background Reference 02
Lacombe, A., et al. Am. J. Hum. Genet. 79 (1) :113-119 (2006)
Background Reference 03
Bione, S., et al. Hum. Reprod. 19 (12) :2759-2766 (2004)
Background Reference 04
Bione, S., et al. Semin. Reprod. Med. 18 (1) :51-57 (2000)
Other Product Names
Protein POF1B, Premature ovarian failure protein 1B, POF1B
Tested Applications
WB
Protein ID
332278224
Physical Properties
Liquid
Curated Selection
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