Mouse Acvr1 Antibody

Product Specifications

Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.

NCBI Gene ID

11477

Swiss Prot

P37172

Accession Number

P37172

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Mouse Acvr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of mouse Acvr1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Symbol

Acvr1

NCBI Official Name

Activin receptor type-1

NCBI Organism

Mus musculus

Background Reference 01

Luo, J., et al. J. Biol. Chem. 285 (38) :29588-29598 (2010)

Background Reference 02

Song, G.A., et al. J. Biol. Chem. 285 (29) :22542-22553 (2010)

Background Reference 03

Shimogori, T., et al. Nat. Neurosci. 13 (6) :767-775 (2010)

Background Reference 04

Suzuki, Y., et al. J. Cell. Sci. 123 (PT 10), 1684-1692 (2010) :

Other Product Names

Activin receptor type-1, Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, TSK-7L, Acvr1, Acvrlk2, Tgfb1