GDI2 Antibody

Product Specifications

Background

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

NCBI Gene ID

2665

Swiss Prot

P50395

Accession Number

P50395

Host

Rabbit

Reactivity

Human

Immunogen

This GDI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the Central region of human GDI2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

51 kDa

Fragment

Rabbit Ig

Symbol

GDI2

NCBI Official Name

Rab GDP dissociation inhibitor beta

NCBI Organism

Homo sapiens

Background Reference 01

Rikova, K., et al. Cell 131 (6) :1190-1203 (2007)

Background Reference 02

Sun, Z.L., et al. Biochim. Biophys. Acta 1774 (6) :764-771 (2007)

Background Reference 03

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Background Reference 04

Grupe, A., et al. Am. J. Hum. Genet. 78 (1) :78-88 (2006)

Other Product Names

Rab GDP dissociation inhibitor beta, Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2, GDI2, RABGDIB

Tested Applications

WB, IHC-P

Protein ID

13638228

Physical Properties

Liquid

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