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G3BP1 Antibody

Product Specifications

Background

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

NCBI Gene ID

10146

Swiss Prot

Q13283

Accession Number

Q13283

Host

Rabbit

Reactivity

Human

Immunogen

This G3BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the C-terminal region of human G3BP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

52 kDa

Fragment

Rabbit Ig

Symbol

G3BP1

NCBI Official Name

Ras GTPase-activating protein-binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Gao, X., et al. FEBS Lett. 584 (16) :3525-3532 (2010)

Background Reference 02

Ortega, A.D., et al. J. Cell. Sci. 123 (PT 16), 2685-2696 (2010) :

Background Reference 03

Hinton, S.D., et al. Biochem. J. 427 (3) :349-357 (2010)

Background Reference 04

Shim, J.H., et al. Cancer Prev Res (Phila) 3 (5) :670-679 (2010)

Other Product Names

Ras GTPase-activating protein-binding protein 1, G3BP-1, ATP-dependent DNA helicase VIII, hDH VIII, GAP SH3 domain-binding protein 1, G3BP1, G3BP

Tested Applications

WB, IHC-P

Protein ID

14916572

Physical Properties

Liquid

Curated Selection

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