CBX5 Antibody

Product Specifications

Background

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

NCBI Gene ID

23468

Swiss Prot

P45973

Accession Number

P45973

Host

Rabbit

Reactivity

Human

Immunogen

This CBX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human CBX5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CBX5

NCBI Official Name

Chromobox protein homolog 5

NCBI Organism

Homo sapiens

Background Reference 01

Nozawa, R.S., et al. Nat. Cell Biol. 12 (7) :719-727 (2010)

Background Reference 02

Zeng, W., et al. Epigenetics 5 (4) :287-292 (2010)

Background Reference 03

Emelyanov, A.V., et al. J. Biol. Chem. 285 (20) :15027-15037 (2010)

Background Reference 04

Kiyomitsu, T., et al. J. Cell Biol. 188 (6) :791-807 (2010)

Other Product Names

Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, CBX5, HP1A

Tested Applications

Protein ID

1170338

Physical Properties

Liquid

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