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RANGAP1 Antibody

Product Specifications

Background

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

NCBI Gene ID

5905

Swiss Prot

P46060

Accession Number

P46060

Host

Rabbit

Reactivity

Human

Immunogen

This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-264

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Symbol

RANGAP1

NCBI Official Name

Ran GTPase-activating protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Zhang, J., et al. Biochem. Biophys. Res. Commun. 375 (2) :252-255 (2008)

Background Reference 02

Zuccolo, M., et al. EMBO J. 26 (7) :1853-1864 (2007)

Background Reference 03

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

Background Reference 04

Vertegaal, A.C., et al. Mol. Cell Proteomics 5 (12) :2298-2310 (2006)

Other Product Names

Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD

Tested Applications

WB, IHC-P

Protein ID

1172922

Physical Properties

Liquid

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