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ARHGDIB Antibody

Product Specifications

Background

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs) . The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]) .

NCBI Gene ID

397

Swiss Prot

P52566

Accession Number

P52566

Host

Rabbit

Reactivity

Human

Immunogen

This ARHGDIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human ARHGDIB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-239

Calculated Molecular Weight

23 kDa

Fragment

Rabbit Ig

Symbol

ARHGDIB

NCBI Official Name

Rho GDP-dissociation inhibitor 2

NCBI Organism

Homo sapiens

Background Reference 01

Niu, H., et al. Oncol. Rep. 24 (2) :465-471 (2010)

Background Reference 02

Zhen, H., et al. Int. J. Gynecol. Cancer 20 (3) :316-322 (2010)

Background Reference 03

Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

Background Reference 04

Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :

Other Product Names

Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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