CTTN Antibody

Product Specifications

Background

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

NCBI Gene ID

2017

Swiss Prot

Q14247

Accession Number

Q14247

Host

Rabbit

Reactivity

Human

Immunogen

This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Symbol

CTTN

NCBI Official Name

Src substrate cortactin

NCBI Organism

Homo sapiens

Background Reference 01

Croucher, D.R., et al. Mol. Cell. Biol. 30 (21) :5057-5070 (2010)

Background Reference 02

Eiseler, T., et al. J. Biol. Chem. 285 (24) :18672-18683 (2010)

Background Reference 03

Xu, X.Z., et al. Mod. Pathol. 23 (2) :187-196 (2010)

Background Reference 04

Saitoh, Y., et al. Int. J. Oncol. 35 (6) :1277-1288 (2009)

Other Product Names

Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1

Tested Applications

WB, IHC-P

Protein ID

215273892

Physical Properties

Liquid

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