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TLR7 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.

NCBI Gene ID

51284

Swiss Prot

Q9NYK1

Accession Number

Q9NYK1

Host

Rabbit

Reactivity

Human

Immunogen

This TLR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-926 amino acids from the C-terminal region of human TLR7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-215

Calculated Molecular Weight

121 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TLR7

NCBI Official Name

Toll-like receptor 7

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Manuse, M.J., et al. Virology 405 (2) :383-389 (2010)

Background Reference 03

Cros, J., et al. Immunity 33 (3) :375-386 (2010)

Background Reference 04

Shen, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (36) :15838-15843 (2010)

Other Product Names

Toll-like receptor 7, TLR7

Tested Applications

WB

Protein ID

20140876

Physical Properties

Liquid

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