HBG1 Antibody

Product Specifications

Background

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1) . The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

NCBI Gene ID

3047

Swiss Prot

P69891

Accession Number

P69891

Host

Rabbit

Reactivity

Human

Immunogen

This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human HBG1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

16 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HBG1

NCBI Official Name

Hemoglobin subunit gamma-1

NCBI Organism

Homo sapiens

Background Reference 01

Zhou, D., et al. Nat. Genet. 42 (9) :742-744 (2010)

Background Reference 02

Miccio, A., et al. Mol. Cell. Biol. 30 (14) :3460-3470 (2010)

Background Reference 03

Nuinoon, M., et al. Hum. Genet. (2009) In press :

Background Reference 04

Da Cunha, A.F., et al. Hemoglobin 33 (6) :439-447 (2009)

Other Product Names

Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1

Tested Applications

Protein ID

56749860

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GTR15175950 1 Vial

Lentiviral mouse Cog4 shRNA (UAS) - Lentiviral mouse Cog4 shRNA (UAS) (100)

Ask

View Details

abx956624-01 150 µg

Human ZC3H11A shRNA Plasmid

Ask

View Details

abx956624-02 300 µg

Human ZC3H11A shRNA Plasmid

Ask

View Details

TRC-D499280-25MG 25 mg

(2R)-3-(((((1S,2S,3R,4S,5S,6S)-2,6-Dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Ask

View Details

ABD4140 100 µg

LILRA2 Antibody

Ask

View Details

MBS650512-01 0.1 mg

MEC, Recombinant, Mouse (CCL28, Mucosae Associated Epithelial Chemokine, Chemokine (C-C motif) ligand 28)

Ask

View Details