P4HA3 Antibody

Product Specifications

Background

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

NCBI Gene ID

283208

Swiss Prot

Q7Z4N8

Accession Number

Q7Z4N8

Host

Rabbit

Reactivity

Human

Immunogen

This P4HA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the Central region of human P4HA3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

P4HA3

NCBI Official Name

Prolyl 4-hydroxylase subunit alpha-3

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J. Phd, et al. Mol. Med. (2010) In press :

Background Reference 02

Koivunen, P., et al. J. Biol. Chem. 281 (39) :28712-28720 (2006)

Background Reference 03

Kukkola, L., et al. J. Biol. Chem. 278 (48) :47685-47693 (2003)

Background Reference 04

Van Den Diepstraten, C., et al. Circulation 108 (5) :508-511 (2003)

Other Product Names

Prolyl 4-hydroxylase subunit alpha-3, 4-PH alpha-3, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3, P4HA3

Tested Applications

Protein ID

74738714

Physical Properties

Liquid

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