TRIM23 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.

NCBI Gene ID

373

Swiss Prot

P36406

Accession Number

P36406

Host

Rabbit

Reactivity

Human

Immunogen

This TRIM23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the N-terminal region of human TRIM23.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Symbol

TRIM23

NCBI Official Name

E3 ubiquitin-protein ligase TRIM23

NCBI Organism

Homo sapiens

Background Reference 01

Arimoto, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (36) :15856-15861 (2010)

Background Reference 02

Poole, E., et al. J. Virol. 83 (8) :3581-3590 (2009)

Background Reference 03

Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

Background Reference 04

Vichi, A., et al. Proc. Natl. Acad. Sci. U.S.A. 102 (6) :1945-1950 (2005)

Other Product Names

E3 ubiquitin-protein ligase TRIM23, 632-, ADP-ribosylation factor domain-containing protein 1, GTP-binding protein ARD-1, RING finger protein 46, Tripartite motif-containing protein 23, TRIM23, ARD1, ARFD1, RNF46