FOLR3 Antibody

Product Specifications

Background

This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively.

NCBI Gene ID

2352

Swiss Prot

P41439

Accession Number

P41439

Host

Rabbit

Reactivity

Human

Immunogen

This FOLR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human FOLR3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FOLR3

NCBI Official Name

Folate receptor gamma

NCBI Organism

Homo sapiens

Background Reference 01

O'Byrne, M.R., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (8) :689-694 (2010)

Background Reference 02

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 03

Boyles, A.L., et al. Genet. Epidemiol. 33 (3) :247-255 (2009)

Background Reference 04

Franke, B., et al. Birth Defects Res. PartClin. Mol. Teratol. 85 (3) :216-226 (2009)

Other Product Names

Folate receptor gamma, FR-gamma, Folate receptor 3, FOLR3

Tested Applications

Protein ID

1169723

Physical Properties

Liquid

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