REC8 Antibody
Product Specifications
Background
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
NCBI Gene ID
9985
Swiss Prot
O95072
Accession Number
O95072
Host
Rabbit
Reactivity
Human
Immunogen
This REC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the Central region of human REC8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
REC8
NCBI Official Name
Meiotic recombination protein REC8 homolog
NCBI Organism
Homo sapiens
Background Reference 01
Aston, K.I., et al. Hum. Reprod. 25 (6) :1383-1397 (2010)
Background Reference 02
Erenpreisa, J., et al. Exp. Cell Res. 315 (15) :2593-2603 (2009)
Background Reference 03
Griffin, J., et al. Syst Biol Reprod Med 54 (3) :163-165 (2008)
Background Reference 04
Xu, H., et al. Dev. Cell 8 (6) :949-961 (2005)
Other Product Names
Meiotic recombination protein REC8 homolog, Cohesin Rec8p, REC8, REC8L1
Tested Applications
WB
Physical Properties
Liquid
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