DOK7 Antibody
Product Specifications
Background
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
285489
Swiss Prot
Q18PE1
Accession Number
Q18PE1
Host
Rabbit
Reactivity
Mouse
Immunogen
This DOK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human DOK7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DOK7
NCBI Official Name
Protein Dok-7
NCBI Organism
Homo sapiens
Background Reference 01
Bergamin, E., et al. Mol. Cell 39 (1) :100-109 (2010)
Background Reference 02
Srour, M., et al. Neuromuscul. Disord. 20 (7) :453-457 (2010)
Background Reference 03
Maselli, R.A., et al. Hum. Mol. Genet. 19 (12) :2370-2379 (2010)
Background Reference 04
Ben Ammar, A., et al. J. Neurol. 257 (5) :754-766 (2010)
Other Product Names
Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25
Tested Applications
WB
Protein ID
115311705
Physical Properties
Liquid
Frequently Asked Questions
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