NFE2 Antibody

Product Specifications

Background

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR) . This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

NCBI Gene ID

4778

Swiss Prot

Q16621

Accession Number

Q16621

Host

Rabbit

Reactivity

Human

Immunogen

This NFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-340 amino acids from the C-terminal region of human NFE2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NFE2

NCBI Official Name

Transcription factor NF-E2 45 kDa subunit

NCBI Organism

Homo sapiens

Background Reference 01

Wang, W., et al. Blood 116 (2) :254-266 (2010)

Background Reference 02

Zhou, Z., et al. J. Biol. Chem. 285 (21) :15894-15905 (2010)

Background Reference 03

Motohashi, H., et al. Blood 115 (3) :677-686 (2010)

Background Reference 04

Lee, T.L., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (1) :52-57 (2010)

Other Product Names

Transcription factor NF-E2 45 kDa subunit, Leucine zipper protein NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2, NFE2

Tested Applications

Protein ID

6831585

Physical Properties

Liquid

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