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SMC1A Antibody

Product Specifications

Background

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq].

NCBI Gene ID

8243

Swiss Prot

Q14683

Accession Number

Q14683

Host

Rabbit

Reactivity

Human

Immunogen

This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-109

Calculated Molecular Weight

143 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SMC1A

NCBI Official Name

Structural maintenance of chromosomes protein 1A

NCBI Organism

Homo sapiens

Background Reference 01

Limongelli, G., et al. Am. J. Med. Genet.152A (8), 2127-2129 (2010) :

Background Reference 02

Homme, C., et al. Oncol. Rep. 24 (1) :47-56 (2010)

Background Reference 03

Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :

Background Reference 04

Wong, R.W. Cell Cycle 9 (1) :198-200 (2010)

Other Product Names

Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SMC1A, DXS423E, KIAA0178, SB18, SMC1, SMC1L1

Tested Applications

WB

Protein ID

29336622

Physical Properties

Liquid

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